Product Description

From the author of the Pulitzer Prize-winning The Beak of the Finch, the riveting story of a biologist's search for the foundations of behavior.

Looking over the shoulder of some of the premier scientists in the filed, Jonathan Weiner takes us into their laboratories to show us how pieces of DNA actually shape behavior. He focuses on the work of Seymour Benzer, who, decades ago, with James Watson and Francis Crick, helped to crack the genetic code. Then, in a simple experiment using a few test tubes, a light bulb, and 100 fruit flies, Benzer invented the genetic dissection of behavior. Now we see how he and his students find and study genes that build our inner clocks, genes that shape the way we love, and genes that decide what we can (or cannot) remember. These breakthroughs help explain secrets of human behavior and may lead to advance treatments for behavioral disorders ranging from rage to autism to schizophrenia.

In a narrative that sweeps from the first years of the century to the present, Weiner makes the process of scientific discovery and understanding almost tangible on the page. Time, Love, Memory is a brilliant work of scientific reportage.

Product Details

• Amazon Sales Rank: #1019236 in Books
• Published on: 1999-04-20
• Released on: 1999-04-20
• Original language: English
• Binding: Hardcover
• 320 pages

From Amazon.com
In the words of Jonathan Weiner, "Time, love, and memory are ... three cornerstones of the pyramid of behavior." While some find it difficult to view humans as mere machines, molecular biologists maintain that most behavior is genetically based. Even skeptics and opponents agree that molecular biology may well change the way we all live in the 21st century. Little-known outside this exploding field, Seymour Benzer, his mentors, and his generations of students have studied the common fruit fly, Drosophila, and discovered genes that seem to have some influence upon our internal clock, our sexuality, and our ability to learn from our experiences.

Weiner (whose last book, The Beak of the Finch, won a Pulitzer Prize) has written an affectionate history about the development of the science while offering charming glimpses of the people involved--trading haircuts to stretch their grant money in the early years, roaming the laboratory into the wee hours, naming the genes associated with learning after Pavlov's dogs. It's not all sweetness and light, however; ethical questions are raised, some of the hype (and hysteria) surrounding the human genome project is dissipated, and the complicated "clockwork" gene "looks less like an invitation to human intervention and more like a cautionary tale or object lesson for anyone who might try, in the 21st century, to improve on nature's four-billion-year-old designs." That said, the scientists in Weiner's tale reveal a very human side of this fast-moving science, and their belief that they'll find answers to important questions is contagious and compelling. As Benzer himself said, "It's a wonderful, fabulous world, and it's been kicking around a long time." --C.B. Delaney

From Publishers Weekly
From the winner of the 1995 Pulitzer for nonfiction (for The Beak of the Finch) comes a vigorously engrossing scientific biography that brings out from the shadows one of the unsung pioneers of molecular biology: brash, eccentric, Brooklyn-born California Institute of Technology physicist-turned-biologist Seymour Benzer. In 1953Athe year Francis Crick and James Watson discovered the structure of DNAABenzer, then at Purdue, invented a way to use viral DNA to map the interior of a gene. Benzer's mapping techniques would help Crick crack the genetic code in the early 1960s. Forsaking viruses and E. coli bacteria for the fruit fly, in the mid-1960s, Benzer began tracking tiny genetic mutations in scores of generations passing through his contraptionAa maze of test-tube tunnels with a light source to which the flies instinctively gravitated. With his wife, neuropathologist Carol Miller, Benzer discovered that the fly brain and the human brain surprisingly share nearly identical genetic sequences. Today their fellow scientists, using mutant fruit flies or mice, attempt to throw light on the genetic coding of memory, learning, courtship, sex assignment, disease and aging. An unresolved question hangs over this enterprise: Will solid links between genes and human behavior ever be established? Weiner answers with a cautious "yes" in this elegantly written scientific detective story told with panache and great lucidity. Benzer, a free spirit with a taste for crashing Hollywood funerals and eating strange food (filet of snake, crocodile tail), may lack the charisma of his Caltech colleague, the late physicist Richard Feynman, but, through Weiner's absorbing presentation, his unorthodox ways in and out of the laboratory will grow on readers. 50 illustrations. Agent, Victoria Pryor. BOMC dual main selection; first serial to the New Yorker.
Copyright 1999 Reed Business Information, Inc.

From Library Journal
Armed with only a few test tubes, a light bulb, and 100 fruit flies, physicist-turned-biologist Seymour Bezmour revolutionized molecular biology. Weiner's fascinating book recounts how Bezmour's beautifully simple experiments revealed the genetic origins of human behavior. (LJ 5/15/99)
Copyright 2000 Reed Business Information, Inc.

Customer Reviews

Timeless
An evocative and wholely compelling portrait of one man that illiminates some of the most significant insights in 20th century biology. Marvelously done. An excellent introduction to molecular genetics. Literary, insightful, witty and precise.

Looking at little people with wings
Far, far back in time, a group of molecules, tangled in crystals of clay, learned the trick of replication. Over time, joined by other molecules of similar talent, they grew complex, finally forming organisms. Seeking food, needing rest, hiding from hungry fellows, developing sex as an offshoot of replication skills, patterns of activity emerged - behaviour. The molecules altered form as external environment changed. Successful changes were kept, while others were left inert in storage. None were discarded, and those controlling basic body structure and fundamental behaviour patterns remained intact across the wide span of living things. After over 3 billion years of life traversing this path, one of the organisms set out to determine how it all worked.

Jonathan Weiner's relation of a century of research teasing into view DNA's mechanisms for guiding behaviour is a brilliant piece of science writing. His focus is Seymour Benzer and his research team studied flies, recording how changing conditions modified conduct. It became clear that 'dumb' animals could adapt through learning. Not only adapt, but retain memories to repeat the new behaviour when needed. By the end of the 20th Century, the research began to identify where along the structure of DNA the operational level of these behaviour codes resided. As often as not a single 'letter' change in the gene was found to trigger the change. More immediately, the information revealed in fruit flies was repeated in other animals. Duplicating the finds in mammals has overwhelming implications for humans.

Weiner's account is forcefully presented in a clear, direct style. This book is a supreme example science writing at its very summit. He offer no judgements of his own. It isn't necessary for him to flaunt the victory Benzer's research grants E. O. Wilson's sociobiology. In fact, Weiner's account of Richard Lewontin's objections to relating genetic bases of behaviour to humans simply lets Lewontin hang himself out to dry. Weiner clearly values the effort invested in the research by Benzer, Tim Tully, Chip Quinn, and, of course, the paramount figure of all, Thomas Hunt Morgan who, with Alfred Sturtevant, initiated the work so long ago.

If you wish to gain insight into your place in the natural universe, this book is a must read. If you adhere to the idea that evolution is a progressive path to humans as the ultimate goal, this book is a must read. If you feel that some divinity has plunked you on this planet with a special role, read this book. Whoever you are, read this book.

Flies Ahead of Time
Weiner's biography of Seymore Benzer is a well written history of modern genetics/politics. A loner, a genius, Benzer was clearly years ahead of his time and changed career directions several times to explore areas that fascinated him. Inspite of derision from colleagues, he believed that behaviors are genetically determined traits, not a popular theory. The clever, simple experiments conducted in flies are well described. Would the NIH would have funded his novel theories? It is not stated, yet Benzer appeared to have a successful career spanning many decades. The tale was inspirational, a joy to read, and funny - with flies dancing in conga lines. It induced hope and courage to continue onward - Thanks to Weiner and Benzer!